Carvedilol Versus Other Nonselective Beta Blockers for Variceal Bleeding Prophylaxis and Death: A Network Meta-analysis
نویسندگان
چکیده
Background and AimsWe aimed to perform a network meta-analysis (NWM) examine comparative effectiveness of non-selective beta blockers (NSBBs) on prophylaxis gastroesophageal variceal bleeding (GVB) mortality benefit.
منابع مشابه
Meta-analysis: beta-blockers versus banding ligation for primary prophylaxis of esophageal variceal bleeding.
AIM To perform an updated meta-analysis comparing β-blockers (BB) with endoscopic variceal banding ligation (EVBL) in the primary prophylaxis of esophageal variceal bleeding. MATERIAL AND METHODS Randomized controlled trials were identified through electronic databases, article reference lists and conference proceedings. Analysis was performed using both fixed-effect and random-effect models....
متن کاملMeta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol).
Because carvedilol is a unique vasodilating β blocker (BB) exerting antioxidant activity and pleiotropic effects, it was theorized that it may confer more potent beneficial effects on cardiovascular mortality and morbidity in acute myocardial infarction (AMI) and heart failure (HF) settings. A systematic review and meta-analysis was performed of randomized, controlled, direct-comparison trials ...
متن کاملCost-effectiveness analysis of variceal ligation vs. beta-blockers for primary prevention of variceal bleeding.
Although both beta-blockade (BB) and endoscopic variceal ligation (EVL) are used for primary prevention of variceal bleeding (VB) in patients with cirrhosis with moderate to large esophageal varices (EVs), the more cost-effective option is uncertain. We created a Markov decision model to compare BB and EVL in such patients, examining both cost-effectiveness (cost per life year [LY]) and cost-ut...
متن کاملVariceal Bleeding Prophylaxis: Variceal Banding or Propranolol
Background and Methods: We compared propranolol therapy and endoscopic ligation for the primary prevention of bleeding from esophageal varices.
متن کاملCarvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol.
OBJECTIVE Non-selective β-blockers or endoscopic band ligation (EBL) are recommended for primary prophylaxis of variceal bleeding in patients with oesophageal varices. Additional α-adrenergic blockade (as by carvedilol) may increase the number of patients with haemodynamic response (reduction in hepatic venous pressure gradient (HVPG) of ≥ 20% or to values <12 mm Hg). DESIGN Patients with oes...
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ژورنال
عنوان ژورنال: Journal of clinical and translational hepatology
سال: 2023
ISSN: ['2310-8819', '2225-0719']
DOI: https://doi.org/10.14218/jcth.2022.00130s